Programs

SPI's work centers on one core activity — synthesizing the science — and three ways of putting it to work: advancing research, building community, and making the public case. It is one coherent effort, not four scattered ones.

1. Knowledge & Synthesis

Produces and maintains the authoritative, citation-audited body of work that translates social-pain and endogenous-opioid-system science into a form researchers and clinicians can actually use. Outputs include the primary-care guide on buprenorphine for BPD, literature syntheses, a research prospectus, and clinician-facing training materials. It already exists in substantial form, and every other program depends on it.

2. Research Facilitation

Turns that knowledge into research momentum — connecting researchers, documenting patient-recruitment feasibility, and lowering the barrier to a pilot or trial. The goal is simple: make it cheaper and less risky for a capable team to study this, so that interest converts into a study that actually launches.

3. Community & Demand

Builds and sustains the patient and clinician community that demonstrates a constituency is waiting for this work — through the BPD and CPTSD research-interest registries, a mailing list, and the patient-facing sites bpd.fyi and cptsd.fyi. It is low-cost and compounding.

4. Advocacy & Public Case

Works to shift the public and professional conversation toward buprenorphine as a legitimate mental-health treatment — through writing, journalism, and public comment.

How this work is sustained

SPI has no financial stake in any medication or manufacturer, and we intend to keep it that way. We’re building a funding mix so the work doesn’t depend on any single source: project and research grants; earned revenue from honest, non-promotional clinician education — for example, training for ketamine clinics on the emerging evidence for low-dose buprenorphine; and individual and community giving from the people this work touches directly.

If you fund work like this, partner on research, run a clinic interested in evidence-based training, or want to support the mission, please get in touch.